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The Functional and Translational Immunology of Regulatory T Cells (Tregs), the Anti-Tumor T Cell Response, and Cancer

by Michael A Alexander | 01 September 2014
Category: Medical Academic
Synopsis
Regulatory T cells (Tregs) are a vital component of the T cell immune system by their ability to control T cell responses that would lead to autoimmune disease. Tregs also protect damaged normal cells that are healing from T cells programmed to kill any abnormal cells in the body. Cancer (tumor) develops from normal cells and can express normal self-antigens. Tregs protect precancerous cells as if they were healing damaged cells and inhibit the anti-tumor T cell response by the use of advanced effector mechanisms, which stop the T cell immune system from effectively removing the tumor. The function of cells involved in this process is controlled by the cell membrane activation of intracellular translational pathways interacting with the nucleus that produces transcriptional proteins, which control cellular behavior such as secretion of lymphokines or cell proliferation. This book examines the function and related translational pathways of Tregs, anti-tumor T cells, and cancer cells. It relates that information to the treatment of cancer by examining human clinical trials of new immune cell-based treatments (immunotherapy). The book also proposes ways to improve those treatments by manipulating the translational pathways of immunotherapeutic cells. The hope is that these new treatment proposals stimulate positive thought about the future of cancer immunotherapy.
€225.39
676 Reward Points
Currently out of stock
Delivery in 5-7 Days
Eligible for free delivery

Any purchases for more than €10 are eligible for free delivery anywhere in the UK or Ireland!

Synopsis
Regulatory T cells (Tregs) are a vital component of the T cell immune system by their ability to control T cell responses that would lead to autoimmune disease. Tregs also protect damaged normal cells that are healing from T cells programmed to kill any abnormal cells in the body. Cancer (tumor) develops from normal cells and can express normal self-antigens. Tregs protect precancerous cells as if they were healing damaged cells and inhibit the anti-tumor T cell response by the use of advanced effector mechanisms, which stop the T cell immune system from effectively removing the tumor. The function of cells involved in this process is controlled by the cell membrane activation of intracellular translational pathways interacting with the nucleus that produces transcriptional proteins, which control cellular behavior such as secretion of lymphokines or cell proliferation. This book examines the function and related translational pathways of Tregs, anti-tumor T cells, and cancer cells. It relates that information to the treatment of cancer by examining human clinical trials of new immune cell-based treatments (immunotherapy). The book also proposes ways to improve those treatments by manipulating the translational pathways of immunotherapeutic cells. The hope is that these new treatment proposals stimulate positive thought about the future of cancer immunotherapy.
€225.39
676 Reward Points
Currently out of stock
Delivery in 5-7 Days
Eligible for free delivery

Any purchases for more than €10 are eligible for free delivery anywhere in the UK or Ireland!


Product Details

ISBN - 9781628087161
Format -
Publisher -
Published - 01/09/2014
Categories - All, Books, Education, Medical Academic
No. of Pages - 323
Weight - 636
Edition -
Series - - Not Available
Page Size - 26
Language - en-US
Readership Age - Not Available
Table of Contents - Not Available

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